Label the Structures of a Skeletal Muscle Fiber

A skeletal muscle from the whole organ down to one myofibril: 12 parts.

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Each numbered ring is a button. Use the arrow keys to move between them and Enter to choose. Names are read out in Study, and once a part is answered.

All 12 parts on the diagram

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Start here: 6 main parts 6

  1. Skeletal muscle A whole muscle is an organ. It has muscle fibers, blood vessels, nerve fibers and connective tissue.
  2. Epimysium The sheath of dense connective tissue round a whole muscle.
  3. Fascicle A bundle of muscle fibers inside a muscle.
  4. Perimysium The middle layer of connective tissue, wrapping each fascicle.
  5. Muscle fiber One skeletal muscle cell: long, cylindrical and with many nuclei.
  6. Endomysium The thin layer of collagen and reticular fibers round each muscle fiber. It holds the fluid and nutrients that support the fiber.

The muscle as an organ: 4 2

  1. Tendon Tough connective tissue joining muscle to bone. The collagen of the three mysia runs into it, and it fuses with the bone's periosteum.
  2. Blood vessels Vessels running between the fascicles. They bring nutrients and oxygen and remove wastes.

Inside a fiber: 5 4

  1. Sarcolemma The plasma membrane of a muscle fiber.
  2. Nucleus One of the fiber's many nuclei, lying just under the sarcolemma.
  3. Myofibril A long rod of contractile proteins running the length of the fiber. Its banding makes the fiber look striped.
  4. Sarcomere The functional unit of a myofibril. It runs from one Z disc to the next.

How this list was compiled: Read 2026-09-26. OpenStax Anatomy and Physiology 2e, section 10.2 Skeletal Muscle, https://openstax.org/books/anatomy-and-physiology-2e/pages/10-2-skeletal-muscle : each skeletal muscle an organ of muscle fibers, blood vessels, nerve fibers and connective tissue; the epimysium wrapping the whole muscle; fascicles of muscle fibers wrapped by the perimysium; each fiber encased in the endomysium of collagen and reticular fibers holding extracellular fluid and nutrients; the mysia's collagen intertwining with a tendon that fuses with the periosteum; blood vessels for nourishment, oxygen and wastes; muscle fibers long and cylindrical with many nuclei; the sarcolemma as the plasma membrane; myofibrils running the fiber's length and giving the striations; the sarcomere as the functional unit within the myofibril. Licence: own work

The drawing: Drawn for this site by script, 2026-09-26. Own work, nothing traced. Licence: own work

How it works

Label the structures of a skeletal muscle fiber and the muscle around it, zooming in four steps: the whole muscle, a cut across it, one fascicle, and one fiber drawn out. It covers the homework: label the structures found within a skeletal muscle.

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Three wraps

The epimysium wraps the whole muscle. Inside, the perimysium wraps each fascicle, a bundle of fibers. The endomysium wraps each single muscle fiber. All three run into the tendon that joins the muscle to bone.

Inside a fiber

A muscle fiber is one long cell with many nuclei under its membrane, the sarcolemma. It is packed with myofibrils, and each myofibril is a chain of sarcomeres, the units that shorten when the muscle contracts.

  • Epi is upon, peri is around, endo is within: the three wraps go from the whole muscle inward.

Questions and answers

What is the difference between the epimysium, perimysium and endomysium?

They are the three connective tissue layers. The epimysium surrounds the whole muscle, the perimysium surrounds each fascicle, and the endomysium surrounds each muscle fiber.

What is a fascicle?

A bundle of muscle fibers inside a muscle, wrapped in perimysium. A muscle is made of many fascicles.

What is the difference between a muscle fiber and a myofibril?

A muscle fiber is a whole muscle cell. Myofibrils are the long rods of contractile proteins packed inside it, each made of repeating sarcomeres.