How it works
This hemostasis diagram shows how a cut in a small blood vessel is sealed, phase by phase. Classroom physiology only: the page gives no medical advice.
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Vascular and platelet phases
A cut tears the endothelium and lays bare the collagen under it. First the muscle of the wall tightens: a vascular spasm that narrows the vessel. Then platelets stick to the torn edges, held by strings of von Willebrand factor. More platelets pile on until a platelet plug fills the cut.
Coagulation phase
Two pathways start the clotting factors. The extrinsic pathway begins at tissue factor, on damaged cells outside the vessel. The intrinsic pathway begins inside it. Both activate factor X. Along the common pathway prothrombin becomes thrombin, and thrombin turns fibrinogen into fibrin threads that bind the plug into a clot.
- The molecules are simple shapes, drawn far larger than life.
- The quiz accepts vasoconstriction, VWF, factor II and factor I.
Questions and answers
What are the three phases of hemostasis?
The vascular phase, when the vessel narrows; the platelet phase, when platelets plug the cut; and the coagulation phase, when fibrin threads bind the plug into a clot.
What happens in the coagulation phase of hemostasis?
Clotting factors activate one another in a chain. The extrinsic and intrinsic pathways meet at factor X, prothrombin becomes thrombin, and thrombin turns fibrinogen into fibrin. An art labeling activity on this phase asks for these names. The drawing is our own.
What happens in the platelet phase of hemostasis?
Platelets stick to the collagen laid bare by the cut, held there by von Willebrand factor. That is adhesion. More platelets then stick to the first ones, which is aggregation, and together they form the platelet plug.
What is the difference between the intrinsic and extrinsic pathways?
The extrinsic pathway starts outside the blood, at tissue factor on damaged cells. The intrinsic pathway starts inside the vessel, when a clotting factor meets exposed collagen, and has more steps. Both lead to factor X.