How it works
This blood cell formation diagram is a tree. The blood stem cell of bone marrow sits at the top, and each line down is one path of blood cell development. A second view adds the stages in between.
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The main lines
The blood stem cell, also called the hematopoietic stem cell, gives rise to a myeloid stem cell and a lymphoid stem cell. The myeloid stem cell becomes a red blood cell, platelets or a myeloblast, and the myeloblast becomes a neutrophil, an eosinophil or a basophil. The lymphoid stem cell becomes a lymphoblast, then a B lymphocyte, a T lymphocyte or a natural killer cell.
Stage by stage
The second tree shows blood cell maturation on three myeloid lines: proerythroblast, erythroblast and reticulocyte on the way to a red blood cell; megakaryoblast and megakaryocyte before platelets; monoblast, monocyte and macrophage.
- A name ending in -blast is an early, immature cell; -cyte is a later one.
Questions and answers
What is hematopoiesis?
The formation of new blood cells. In an adult it takes place in the bone marrow, where blood stem cells divide and their daughter cells mature step by step into red blood cells, platelets and white blood cells.
Which blood cells come from the myeloid stem cell?
Red blood cells, platelets and the granulocytes: neutrophils, eosinophils and basophils. Monocytes, which become macrophages, are myeloid cells too. Lymphocytes and natural killer cells come from the lymphoid stem cell.
Where do platelets come from?
From megakaryocytes, very large cells of the bone marrow. Platelets are small pieces of a megakaryocyte, not whole cells.
What cells are in a bone marrow cell diagram?
The blood-forming cells of this tree: blood stem cells, the myeloid and lymphoid stem cells, the blasts and the maturing cells of each line.