How it works
A chemical synapse diagram labeled from top to bottom: the sending terminal with its vesicles and calcium channels, the cleft the neurotransmitter crosses, and the receptors on the next cell. It answers the homework: correctly label the following parts of a chemical synapse.
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How the signal crosses
An action potential reaches the terminal and opens voltage-gated calcium channels. Calcium ions flow in and make synaptic vesicles fuse with the membrane, releasing neurotransmitter into the cleft. It crosses and binds to receptors on the postsynaptic membrane.
How it is cleared
The signal has to stop. An enzyme in the cleft can break the neurotransmitter down, or a reuptake transporter can carry it back into the terminal.
- Pre comes before the gap, post comes after: at a chemical synapse the signal only runs one way.
Questions and answers
What is the synaptic cleft?
The narrow gap between the sending and receiving cells, which every chemical signal must cross. The neurotransmitter diffuses across it to reach the receptors.
What does calcium do at a synapse?
When an action potential arrives, calcium channels open and calcium ions flow into the terminal. The calcium makes the vesicles fuse with the membrane and release their neurotransmitter.
How is neurotransmitter removed from the synapse?
By enzymes that break it down in the cleft, or by reuptake into the sending neuron or nearby glial cells.