How it works
The thyroid gland lies in front of the trachea, just below the larynx. The first drawing shows it from the front and from behind; the next two show thyroid tissue and parathyroid tissue as under a microscope.
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From the neck down to the cells
Numbers 1 to 6 are on the gland in the neck: the two lobes, the isthmus that joins them, the larynx above, the trachea behind, and the four parathyroid glands on the back of the lobes. Numbers 7 to 10 are in thyroid tissue: a follicle, its colloid, the follicular cells round it and the parafollicular cells between follicles. Numbers 11 and 12 are the two cell types of a parathyroid gland.
- From the front, the right lobe is on your left. From behind, the sides swap.
- Follicular cells form the wall of a follicle; parafollicular cells lie between follicles.
Questions and answers
What are the cells of the thyroid gland?
Follicular cells form the wall of each follicle and make the thyroid hormones T3 and T4 in the colloid they surround. Parafollicular cells, also called C cells, lie between the follicles and make calcitonin.
What are the cells of the parathyroid gland?
Chief cells are the main working cells: they make parathyroid hormone, which raises the level of calcium in the blood. Oxyphil cells are the second type, and their function is not clear.
What is colloid in the thyroid?
Colloid is the sticky fluid that fills the middle of each thyroid follicle. The thyroid hormones are made in it, on a protein called thyroglobulin, and stay there until the gland is signaled to release them.
Where are the parathyroid glands?
Usually on the back of the thyroid gland, set into its two lobes. Most people have four: two on each side, one above the other.