How it works
Glucose is a sugar with six carbon atoms. In water almost all of it is a ring of five carbons and one oxygen. The ring is labeled atom by atom here, then opened into a chain.
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Number the carbons
Find the ring oxygen. The corner to its right is carbon 1. Count on around the ring, away from the oxygen, to carbon 5. Carbon 6 stands above the ring.
From chain to ring, alpha or beta
On the chain, carbon 1 is at the top, in the aldehyde group. The ring forms when the hydroxyl group on carbon 5 bonds to carbon 1. To tell alpha from beta, look only at carbon 1: its hydroxyl group points down in alpha-glucose, away from the CH₂OH group, and up in beta-glucose.
- The thick edge of a ring is the side nearest you.
- A group on the right of the chain points down in the ring.
Questions and answers
What is the chemical formula of glucose?
C₆H₁₂O₆: six carbon, twelve hydrogen and six oxygen atoms. All 24 are on the ring drawing. Five of the oxygen atoms are in hydroxyl groups and the sixth is the ring oxygen.
How are the carbons in glucose numbered?
From the aldehyde end of the chain. Carbon 1 carries the aldehyde group, and in the ring it sits next to the ring oxygen. Carbons 2 to 5 follow in order around the ring, and carbon 6 is outside it.
What is the difference between alpha and beta glucose?
Only the hydroxyl group on carbon 1: down in the alpha ring, up in the beta ring. In water the two change into each other, about 36 percent alpha to 64 percent beta. Starch is built from alpha rings, cellulose from beta.
Why is glucose drawn as a ring and as a chain?
Both are the same molecule. The chain closes into a ring when the hydroxyl group on carbon 5 bonds to carbon 1, and the ring can open again. In water nearly all glucose is in a ring form.