Plasma Membrane Worksheet

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  1. 1.Which model describes the plasma membrane as a moving patchwork of lipids, proteins and carbohydrates?
  2. 2.What forms the main fabric of the plasma membrane?
  3. 3.Which part of a phospholipid faces the watery fluid inside and outside the cell?
  4. 4.Where are the hydrophobic tails of the phospholipids?
  5. 5.What does cholesterol do in an animal cell membrane?
  6. 6.Carbohydrate chains attached to membrane proteins form…
  7. 7.What job do the carbohydrates on the outer surface of the membrane do?
  8. 8.Proteins that span the whole membrane are called…
  9. 9.About how thick is a plasma membrane?
  10. 10.What does "selectively permeable" mean?
  11. 11.Which phospholipid tails help keep a membrane fluid in the cold?
  12. 12.Membrane receptor proteins do what?
  13. 13.Which molecules cross the membrane easily by simple diffusion?
  14. 14.Why do ions such as Na⁺ and K⁺ need a channel to cross the membrane?
  15. 15.Diffusion through a membrane protein, with no energy used, is…
  16. 16.Which channel proteins let water through very fast?
  17. 17.A red blood cell is put in a hypotonic solution (fewer solutes than the cell). What happens?
  18. 18.A red blood cell is put in a hypertonic solution (more solutes than the cell). What happens?
  19. 19.A red blood cell is put in an isotonic solution. What happens?
  20. 20.A plant cell loses water in a hypertonic solution. What is the membrane pulling away from the cell wall called?
  21. 21.Why do plant cells not burst in pure water?
  22. 22.Which change makes diffusion faster?
  23. 23.In osmosis, water moves from…
  24. 24.A cell is 2% salt inside and sits in 5% salt water. Which way does water move?
  25. 25.A cell is 3% salt inside and sits in 1% salt water. Which way does water move?
  26. 26.What does active transport need that passive transport does not?
  27. 27.Active transport moves a substance…
  28. 28.How many sodium and potassium ions does the sodium-potassium pump move in each cycle?
  29. 29.The sodium-potassium pump uses ATP directly. What kind of transport is it?
  30. 30.Secondary active transport (co-transport) gets its energy from…
  31. 31.Glucose is carried into a cell by carrier proteins. What happens when there is more glucose than carriers?
  32. 32.A white blood cell engulfs a bacterium. What is this?
  33. 33.A cell takes in droplets of fluid in small vesicles. What is this?
  34. 34.A cell releases a hormone packed in vesicles that fuse with the membrane. What is this?
  35. 35.Receptor-mediated endocytosis takes in…
  36. 36.Which kind of transport can a dead cell no longer do?
Carbohydrate chains attached to membrane proteins form…

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Unofficial practice questions, not affiliated with any school, textbook publisher or curriculum. Bank checked September 24, 2026.

How it works

This plasma membrane worksheet has 36 questions: phospholipids, cholesterol and proteins in the fluid mosaic model, diffusion and osmosis with cells in hypotonic, isotonic and hypertonic solutions, and pumps, endocytosis and exocytosis.

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Three sets

Membrane structure covers the bilayer, cholesterol, proteins and carbohydrates. Diffusion and osmosis asks which way water moves and what happens to red blood cells and plant cells. Active and bulk transport covers ATP pumps, co-transport and moving big things.

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  • In osmosis, water moves towards the side with more dissolved solute.
  • Hypotonic outside: the cell swells. Hypertonic outside: it shrinks.
  • Down the gradient is passive; up the gradient needs energy, usually from ATP.

Questions and answers

What is the plasma membrane made of?

A double layer of phospholipids with hydrophilic heads facing out and hydrophobic tails inside, plus cholesterol, proteins that carry, channel or receive, and carbohydrate chains on the outer surface.

What is the difference between hypotonic and hypertonic?

A hypotonic solution has fewer solutes than the cell, so water moves in. A hypertonic solution has more, so water moves out. In an isotonic solution there is no net movement.

What is the difference between active and passive transport?

Passive transport (diffusion, osmosis, facilitated diffusion) moves substances down their concentration gradient with no energy from the cell. Active transport moves them against it and needs energy, usually ATP.

All 36 questions with answers

Membrane structure 12

  • About how thick is a plasma membrane? Answer: 5 to 10 nm. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • Carbohydrate chains attached to membrane proteins form… Answer: Glycoproteins. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • Membrane receptor proteins do what? Answer: Receive signals such as hormones and pass them into the cell. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • Proteins that span the whole membrane are called… Answer: Integral proteins. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • What does "selectively permeable" mean? Answer: Some substances can cross the membrane and others cannot. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • What does cholesterol do in an animal cell membrane? Answer: Keeps the membrane's fluidity steady as temperature changes. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • What forms the main fabric of the plasma membrane? Answer: A double layer of phospholipids. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • What job do the carbohydrates on the outer surface of the membrane do? Answer: Help cells recognise each other, "self" from "non-self". Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
Show all 36 questions (28 more)

Membrane structure, continued

  • Where are the hydrophobic tails of the phospholipids? Answer: In the middle of the membrane, away from water. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • Which model describes the plasma membrane as a moving patchwork of lipids, proteins and carbohydrates? Answer: The fluid mosaic model. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • Which part of a phospholipid faces the watery fluid inside and outside the cell? Answer: The hydrophilic (water-loving) head. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.
  • Which phospholipid tails help keep a membrane fluid in the cold? Answer: Unsaturated tails, whose kinks keep the lipids apart. Source: OpenStax Biology 2e, 5.1 Components and Structure. Read 2026-09-24.

Diffusion and osmosis 14

  • A cell is 2% salt inside and sits in 5% salt water. Which way does water move? Answer: Out of the cell. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • A cell is 3% salt inside and sits in 1% salt water. Which way does water move? Answer: Into the cell. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • A plant cell loses water in a hypertonic solution. What is the membrane pulling away from the cell wall called? Answer: Plasmolysis. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • A red blood cell is put in a hypertonic solution (more solutes than the cell). What happens? Answer: Water moves out and the cell shrivels. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • A red blood cell is put in a hypotonic solution (fewer solutes than the cell). What happens? Answer: Water moves in and the cell swells and may burst. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • A red blood cell is put in an isotonic solution. What happens? Answer: No net water movement; it keeps its shape. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • Diffusion through a membrane protein, with no energy used, is… Answer: Facilitated diffusion. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • Glucose is carried into a cell by carrier proteins. What happens when there is more glucose than carriers? Answer: The carriers are all busy, so the extra glucose waits or is lost. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • In osmosis, water moves from… Answer: Lower solute concentration to higher solute concentration. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • Which change makes diffusion faster? Answer: A higher temperature. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • Which channel proteins let water through very fast? Answer: Aquaporins. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • Which molecules cross the membrane easily by simple diffusion? Answer: Small, uncharged ones such as oxygen and carbon dioxide. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • Why do ions such as Na⁺ and K⁺ need a channel to cross the membrane? Answer: Their charge keeps them out of the non-polar middle of the bilayer. Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.
  • Why do plant cells not burst in pure water? Answer: The rigid cell wall pushes back (turgor pressure). Source: OpenStax Biology 2e, 5.2 Passive Transport. Read 2026-09-24.

Active and bulk transport 10

  • A cell releases a hormone packed in vesicles that fuse with the membrane. What is this? Answer: Exocytosis. Source: OpenStax Biology 2e, 5.4 Bulk Transport. Read 2026-09-24.
  • A cell takes in droplets of fluid in small vesicles. What is this? Answer: Pinocytosis. Source: OpenStax Biology 2e, 5.4 Bulk Transport. Read 2026-09-24.
  • A white blood cell engulfs a bacterium. What is this? Answer: Phagocytosis. Source: OpenStax Biology 2e, 5.4 Bulk Transport. Read 2026-09-24.
  • Active transport moves a substance… Answer: Against its concentration gradient, from low to high. Source: OpenStax Biology 2e, 5.3 Active Transport. Read 2026-09-24.
  • How many sodium and potassium ions does the sodium-potassium pump move in each cycle? Answer: 3 Na⁺ out and 2 K⁺ in. Source: OpenStax Biology 2e, 5.3 Active Transport. Read 2026-09-24.
  • Receptor-mediated endocytosis takes in… Answer: Particular substances that bind to receptors on the membrane. Source: OpenStax Biology 2e, 5.4 Bulk Transport. Read 2026-09-24.
  • Secondary active transport (co-transport) gets its energy from… Answer: Sodium ions flowing back down the gradient the pump built. Source: OpenStax Biology 2e, 5.3 Active Transport. Read 2026-09-24.
  • The sodium-potassium pump uses ATP directly. What kind of transport is it? Answer: Primary active transport. Source: OpenStax Biology 2e, 5.3 Active Transport. Read 2026-09-24.
  • What does active transport need that passive transport does not? Answer: Energy, usually from ATP. Source: OpenStax Biology 2e, 5.3 Active Transport. Read 2026-09-24.
  • Which kind of transport can a dead cell no longer do? Answer: Active transport. Source: OpenStax Biology 2e, 5.3 Active Transport. Read 2026-09-24.

How this list was compiled: Questions, wrong choices and explanations were written for this site. Facts were checked on OpenStax Biology 2e, sections 5.1 to 5.4 (membrane structure, passive, active and bulk transport), read 2026-09-24; each question names its section. Licence: own work